Cell body reorganization in the spinal cord after elective surgery to treat palmar sweating

The amount of compensatory sweating depends on the patient, the damage that the white rami communicans incurs, and the amount of cell body reorganization in the spinal cord after surgery.

Other potential complications include inadequate resection of the ganglia, gustatory sweating, pneumothorax, cardiac dysfunction, post-operative pain, and finally Horner’s syndrome secondary to resection of the stellate ganglion.
www.ubcmj.com/pdf/ubcmj_2_1_2010_24-29.pdf

After severing the cervical sympathetic trunk, the cells of the cervical sympathetic ganglion undergo transneuronic degeneration
After severing the sympathetic trunk, the cells of its origin undergo complete disintegration within a year.

http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0442.1967.tb00255.x/abstract

Spinal cord infarction occurring during thoraco-lumbar sympathectomy
J Neurol Neurosurg Psychiatry 1963;26:418-421 doi:10.1136/jnnp.26.5.418

Saturday, January 19, 2013

after sympathectomy the extremity will be more apt to have disturbance of circulation and is left unprotected from fluctuation in circulation


1. Sympathectomy is analogous to the act of killing the messenger. The sympathetic nervous system has the critical job of properly controlling and preserving the circulation in different parts of the body, especially in the extremities. By paralyzing the system, the extremity will be more apt to have disturbance of circulation and is left unprotected from fluctuation in circulation.
Sympathectomy is similar to permanently removing the central heat and air-conditioning system and never replacing it because of malfunction.
Sympathectomy permanently damages the temperature regulatory system. The reason sympathectomy does not cause side effects other than ineffective control of pain as well as impotence and orthostatic hypotension is because it is invariably partial and incomplete.H. Hooshmand, M.D.: Chronic Pain


9780849386671
Chronic Pain: Reflex Sympathetic Dystrophy Prevention and Management

ISBN 10: 0849386675 / 0-8493-8667-5 
ISBN 13: 9780849386671
Publisher: CRC Pr I Llc
Publication Date: 1993
Binding: Hardcover

Thursday, January 17, 2013

Register all trials, report all results – it's long overdue

Register all trials, report all results – it's long overdue: "If researchers go to the effort of getting funds, recruiting patients, and following them up, you would think that they would be keen to publish the results. So it’s surprising that our best estimates show around half of all completed clinical trials have never been published in academic journals. And the half we have is biased towards trials with positive results."

'via Blog this'

Saturday, January 12, 2013

Bradycardia might occur secondary to unopposed vagal tone from a high sympathectomy


Bradycardia might occur secondary to unopposed vagal tone from a high sympathectomy, blockade of the cardio-accelerator fibers (T1-T4), and the Bezold-Jarisch reflex (slowing of the heart rate secondary to decreased venous return). Patients with underlying increased vagal tone (children and adults with resting heart rates < 60) are at an increased risk.

Anesthesia Secrets, 4th Edition by James Duke, 
Elsevier Health Sciences, 16/03/2010 - 574 pages

The effect of dysfunction of the autonomic nervous system on experienced feelings and emotions


Hohmann, G.W. : The effect of dysfunction of the autonomic nervous system on experienced feelings and emotions
Paper read at Conference on Emotions and Feelings at New School for Social Research, New York, Oct 1962.
Sherrington, C.S.: Experiments on the value of vascular and visceral factors for the genesis of emotion 
Proc. Roy.Soc., 1900, 66, 390-403
Wenger, M.A.: Emotion as visceral action: an extension of Lange's theory. In Reymert, M.L., Feelings and emotions: the Moosehart ymposium, New York: McGraw-Hill, 1950. Pp.3-10.
Wynne, L.C., and Solomon, R.L.: Traumatic avoidance learning: acquisition and extinction in dogs deprived of normal peripheral autonomic function. 
Genet. psychol. Monogr., 1955, 52, 241-84
Landis, C., and Hunt, W. A. Adrenalin and emotion. 
Psychol. Rev., 1932, 39, 467-85.
Schachter, S., and Wheeler, L.: Epinephrine, chlorpromazine, and amusement. 
J. of abnorm. soc. Psychol., 1962, 65, 121-28.

Friday, January 4, 2013

Complications of endoscopic sympathectomy - hypoxia, hypotension, haemothorax, pneumothorax



"there are some potentially serious anaesthetic sequelae. Despite the use of various analgesic techniques, including intrapleural bupivacaine and systemic opioids, postoperative chest pain is a common and distress- ing feature, with a duration of 12 hours or more.
In a recent prospective study of 58 patients undergoing this procedure, Jedeikin et al reported hypoxia (with an arterial oxygen saturation of 70%) and hypotension (with decrease in arterial pressure to < 50mmHg) as uncommon but important complications.
'These events maybe the result of compression of the mediastinum and major vessels by carbondioxide insufflation. In addition, during bilateral procedures, lesser degrees of hypoxia were common place with deflation of the lung on the second side, despite apparently adequate reinflation of the first lung. 15%  of patients had pneumothorax and 7% required underwater drainage for haemothorax or pneumothorax."

A C QUINN R E EDWARDS PJNEWMAN W J FAWCETT

BMJ VOLUME 306 26JUNE1993

Thursday, January 3, 2013

It has been shown in animals that sympathectomy of one side of the body leads to an increase in the development of tumors on the denervated side


Coujard R, Heitz F. Cancerologic: Production de tumeurs malignes consecutives a des lesions des fibres sympathiques du nerf sciatique chez le Cobaye. C R Acad Sci 1957; 244: 409-411. 

Besedovsky H, DelRey A, Sorkin E, DaPrada M, Keller H. Immunoregulation mediated by the sympathetic nervous system. Cellular Immun 1979; 48:346-355. 

Stein-Werblowsky R. The sympathetic nervous system and cancer. Exper Neuro 1974; 42:97-100. 

Delrey A, Besedovsky H, Sorkin E, DaPrada M, Arrenbrecht S. Immunoregulation mediated by the sympathetic nervous system, II. Mol Immunol 1981; 63:329-334.

Wednesday, January 2, 2013

in the absence of autonomic arousal, behavior that appears emotional will not be experienced as emotional


"In the presence of a barking dog, for example, the sympathectomized cats manifested almost all of the signs of feline rage. Finally, Cannon notes the report of Dana (1921) that a patient with a spinal-cord lesion and almost totally without visceral sensation still manifested emotionality.
For either the Jamesian or the present formulation such data are crucial, since both views demand visceral arousal as a necessary condition for emotional arousal. When faced with this evidence, James's defenders (e.g., Wenger, 1950; Mandler, 1962) have consistently made the point that the apparently emotional behavior manifested by sympathectomizied animals and men is well-learned behavior, acquired long before sympathectomy. There is a dual implication in this position: first, that sympathetic arousal facilitates the acquisition of emotional behavior, and second, that sympathectomized subjects act but do not feel emotional. There is a small but growing evidence supporting these contentions. Wynne and Solomon (1955) have demonstrated that sympathectomized dogs acquire an avoidance response considerably more slowly than control dogs. Further, on extinction trials most of their 13 sympathectomized animals extinguished quickly, whereas not a single one of the 30 control dogs gave any indication of extinction over 200 trials. Of particular interest are two dogs who were sympathectomized after they had acquired the avoidance response. On extinction trials these two animals behaved precisely like the control dogs - giving no indication of extinction. Thus, when deprived of visceral innervation, animals are quite slow in acquiring emotionally-linked avoidance responses and in general, quick to extinguish such responses." (p. 163)

"A line of thought stimulated by the Wynne and Solomon (1955) and the Hohmann (1962) studies may indeed be the answer to Cannon's observations that there can be emotional behavior without visceral activity. From the evidence of these studies, it would appear, first, that autonomic arousal greatly facilitates the acquisition of emotional behavior but it is not necessary for its maintenance if the behavior is acquired prior to sympathectomy; and second, that in the absence of autonomic arousal, behavior that appears emotional will not be experienced as emotional." (p. 167)

Psychobiological Approaches to Social Behavior

P. Herbert LeidermanDavid ShapiroHarvard Medical School. Dept. of PsychiatryUnited States. Office of Naval Research - 1964 - 203 pages